Paranoia is not an uncommon response to heavy doses of cocaine. The drug may also
trigger psychosis in users who are prone to mental instability. Repeated
inhalation often results in nostril and nasal membrane irritation. Injection with
nonsterile equipment can transmit AIDS and other infections.
Some regular users have reported feelings of restlessness, irritability, and
anxiety. Others have experienced hallucinations of touch, sight, taste, or smell.
When people stop using cocaine after taking it for a long time, they frequently
become depressed. They tend to fight off this depression by taking more cocaine, just as
in the up/down cycle amphetamine cycle.
Cocaine is toxic. Although few people realize it, overdose deaths from injected,
oral, and even snorted cocaine have occurred. The deaths are a result of seizures followed
by respiratory arrest and coma, or sometimes by cardiac arrest.
Cocaine death are rare. But a pervasive public health problem could easily
result if smoking base cocaine continues to catch on.